High-shear single-pot granulation has been used in the pharmaceutical industry for many decades. Single-pot granulation combines the mixing, high-shear wet granulation and drying (vacuum drying, carrier-gas drying, or microwave drying) all in one process bowl. L.B. Bohle's single-pot granulation portfolio includes R&D systems for small production volumes as well as production-scale systems.
Granulation with the Bohle Single Pot Granulator
The VMA product range includes classic single-pot granulators with agitator and chopper units and a top drive. Two stirrers produce the shearing action and loosen the product. This helps to prevent clumping and ensures that the resulting granule is of optimum quality. The GMP-compliant process bowl with a double shell is the core of the VMA.
The main aggregates are integrated in the lid of the granulation pot (top drive). The process bowl is emptied through a cone-shaped sieve (BTS 200) via the floor outlet into a container (IBC). Recipe-controlled cleaning is carried out automatically. The VMA produces batch sizes from 20 to 960 litres and can be installed in explosive atmospheres.
Benefits of the Bohle Single Pot Granulator
- Safe production inside a closed bowl in a vacuum
- High mixing and granulation efficiency (even for low doses of active agents at < 1%)
- Drying at low temperatures
- Small product contact surface for fast, easy cleaning and fast product switching
- Efficient solvent recovery through cooling water
Bohle Single Pot Granulator picture gallery
Technical Data: Bohle Single Pot Granulator
|VMA 70||VMA 300||VMA 600||VMA 1200|
|Overall dimensions (LxWxH)||1800x1300x2500||2290x1650x2950||2525x1850x3350||3365x2150x4400|
|Control system||PLC, Visualisierung In Touch von Wonderware|
Available types of the Bohle Single Pot Granulator
- VMA 10
- VMA 70
- VMA 300
- VMA 600
- VMA 1200
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