Dry granulation is often the process of choice for large-volume or moisture-sensitive products. The roller compactors from Bohle are suitable for batch and continuous production. Furthermore, the granulators of the BRC series can be integrated into various production scenarios. Process Analytical Technology (PAT) can be integrated.

 

Roller Compaction / Dry Granulation - BRC 25 and BRC 100

Roller Compactor BRC 25

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Roller Compactor BRC 100

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Continuous Processes with Dry Granulation - Bohle Roller Compactor BRC 25 and BRC 100

In the dry granulator powders are processed into fluid granules. The objective in the pharmaceutical industry is to process a granule with defined density or porosity for immediate tabeletting thereafter. The powder is fed via a dosing unit, compacted between two rollers with gaps ranging from 1 to 6 mm and discharged as scabs.

The impact on the rollers, as well as the gap width are monitored sensorially and integrated into a control circuit to ensure continuous optimum process parameters.

The chopper unit below the compact rollers processes scabs into granules. The unit is equipped with a conical sieve with exchangeable sieve units for processing different particle sizes.

Innovative electro-mechanical drive

Especially the control of the pressing force via standard hydraulic systems constitutes a great problem, when the process is aimed to comply with “hygienic design”. With the innovative electro-mechanical batch L.B. Bohle is able to solve this problem.

With the Bohle BRC dry granulator, frequent axis adjustment as with traditional roller compactors is a thing of the past. Thanks to a special bearing method, the axes are mechanically stable so that elastic deformation is prevented. This eliminates the need for complete axes control!

Easy Handling and Cleaning

Moreover, the dry granulator BRC is low maintenance. Even when cleaning is required, only four screws must be removed. Furthermore, Bohle engineers reduced the overall height by 20 percent.

Bohle Roller Compactor - suitable for your batch or continuous manufacturing

The BRC 25 can be used as a stand-alone unit or integrated in L.B. Bohle´s continuous manufacturing unit QbCon® for your dry granulation process.

Bohle is now able to offer the customers machines and processes for all stages of the granulation process with the BRC – continuously, and with the proven Bohle quality.

The advantages of the Bohle Roller Compactor BRC Dry Granulator

  • Minimal material loss due to precise control of the compression force with an innovative electromechanical roller drive
  • Constant ribbon properties assured with sensitive gap width control
  • Easy handling and short mounting procedures
  • Hygienic design and effective cleaning by integrated WIP nozzles
  • Versatile and gentle particle size adjustment with integrated Bohle Turbo Sieve (BTS 200)
  • PAT tool integration possible

 

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Scientic Analysis about the Bohle Roller Compactor BRC 100

Learn more about the continuous manufacturing unit QbCon®

L.B. Bohle QbCon®

 

Technology CenterContinuous Manufacturing

From Powder to the coated tablet: The unique feature of the production unit QbCon® is that the tablet production can be implemented either without granulation or with dry or wet granulation, in one system.

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Service CenterComplete Solid Dosage Production

The Bohle Service Center enables the presentation and testing from our machines as well as the executions of workshops and tutorials.

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InnovativIssue: 1-2018

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