Continuous dry granulation has been an established process in the pharmaceutical industry for decades and is used for more than just moisture- or temperature-sensitive products.
Unlike classic wet granulation methods, this process does not require any energy-intensive drying processes; this avoids the need for large investments in systems and production facilities, and lowers the costs per batch.
Dry granulation is frequently the preferred approach for very bulky or moisture-sensitive products. L.B. Bohle's BRC granulators are suitable for continuous production and can be integrated with Process Analytical Technology (PAT). For this purpose, the BRC series granulators offer flexibility for integration into a wide variety of production scenarios.
Granulation with the Roller Compactor BRC
L.B. Bohle’s BRC series combines high product capacity with minimal material loss. This system outclasses rival solutions by generating force through purely electromechanical means to ensure consistent ribbon properties. The BRC uses highly innovative methods to regulate compacting force and ribbon thickness. It compacts material uniformly over a production range of <1 - 400 kg/h. The sophisticated system design facilitates the handling and shortens the assembly process.
The hygienic design and the integrated washer nozzles, fitted as standard, allow for an effective WIP process. Even at high material throughputs, the cone-shaped BTS Bohle Turbo Sieve mill and sieve inserts gently crush the ribbons into granules with the desired particle size distribution. Each BRC can be retooled with a different rotary sieve within minutes to adjust to new process and ribbon requirements.
Thanks to its functional GMP-compliant design and PAT tool support, the compactor meets the requirements of the pharmaceutical “Quality by Design”.
Benefits of the Bohle Roller Compactor
- Minimal material loss due to precise control of the compression force with an innovative electromechanical roller drive
- Sensitive gap width control maintains constant ribbon properties
- Easy to use and quick set-up
- Hygienic design and effective cleaning via WIP nozzles ('washing in place' process)
- Versatile and gentle particle size calibration with integrated Bohle Turbo Sieve (BTS 200)
- Optional PAT integration
- Optional containment equipment including sampling
Bohle Roller Compactor picture gallery
Technical Data: Bohle Roller Compactor
|Machine||BRC 25||BRC 100|
|Capacity [kg/h]||≤ 1 – 100 kg/h (product dependent)||≤ 1 – 400 kg/h (product dependent)|
|Size (L x B x H) [mm]||1900 x 1000 x 1960||1960 x 1410 x 2140|
|Operator Panelg||Siemens Touch Panel||Siemens Touch Panel|
Available types of the Bohle Roller Compactor
- BRC 25
- BRC 100
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