Fluidized bed systems have been used in the pharmaceutical industry for many decades. Adding an aqueous or alcoholic granulation medium compresses the mixture of dry powder particles. The fluid contains a volatile solvent which can be removed by drying. For a long time, fluidized bed solutions were dominated by top-spray systems. However, the benefits of systems with tangential spray nozzles are becoming more and more apparent, and these systems now tend to take over from top-spray granulators. L.B. Bohle's fluid bed granulation portfolio includes R&D systems for small production volumes as well as production-scale systems.
Granulation with the Bohle Fluid Bed Granulator
L.B. Bohle uses the Bohle Uni Cone BUC® process to optimize fluidized bed technology. The patented BUC® Bohle Uni Cone is a specially slotted air distributor plate with a conical displacement cone. This design allows for a complete fluidization of the particles. This tangential particle motion achieves a uniform film, e.g. on pellets, without any twins forming. Since the fluidized particles or granules move tangentially at relatively low fluidization height, they do not require a high-volume expansion. This reduces the required installation height, saving cost and production floor space.
At least six filter elements of the BFS that can be cleaned separately ensure that the air flow though the product bed is uninterrupted.
Drying, granulation and coating without need for alteration
Another advantage of the tangential design in facilities from L.B. Bohle is that granulation, coating and drying can be carried out in a single system without having to reconfigure the equipment.
For the drying process, the BFS fluidized bed system can be equipped with an online moisture measurement system using NIR technology (similar to infra-red analysis). This innovation makes it possible to identify the current moisture level precisely and reproducibly during the granulation and drying process.
Benefits of the Bohle Fluid Bed Granulator
- Complete fluidization of the particles
- Even film coating, no twin formation
- Pressure surge resistance up to 12 bar- optimum conditions for containment applications
- Integration of PAT, NIR and WIP
- Patented filter cleaning – patented diffusor
- Lowering of filters via electric drive
- Easy-to-remove distributor plate
- Low installation height, efficient space utilization
Bohle Fluid Bed Granulator picture gallery
Technical Data: Bohle Fluid Bed Granulator
|BFS series||BFS 30||BFS 60||BFS 120||BFS 240||BFS 360||BFS 480|
|Qty. of product filter bags||4||6||9||12||10|
|Approx. height Fluid Bed [mm]||1980||2930||3600||3920||4570||4990|
|Number of nozzles (Tangential spray)||1||2||3||4||5||6|
|Control system||PLC controlled, Touchpanel operated|
Available types of the Fluid Bed Granulator
- Bohle Fluid Bed System BFS 3
- Bohle Fluid Bed System BFS 30
- Bohle Fluid Bed System BFS 60
- Bohle Fluid Bed System BFS 120
- Bohle Fluid Bed System BFS 240
- Bohle Fluid Bed System BFS 360
- Bohle Fluid Bed System BFS 480
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