Process technology for the pharmaceutical industry


All from a single source

As an expert for special machines, L.B. Bohle develops and implements high-quality systems for manufacturers of pharmaceutical products: from the single machine through to the complete production line. Our success is based on the expansion of our technological leadership in process engineering for granulation and coating. The technological leadership in both core segments secures our growth, profitability and workplaces as well as ensuring our long-term presence on the market.

Bohle experts combine long-term experience in production process with state-of-the-art control techniques. L.B. Bohle offers its customers tailored solutions – all from the same source.


More than 40 patents worldwide

Based on comprehensive development work, L.B. Bohle holds over 40 patents worldwide. The company combines its strategy with a comprehensive orientation vis-à-vis quality. A continuous focus on customers, employees, technologies and processes ensures constant quality improvements. L.B. is certified according to international DIN EN ISO 9001:2008 standards.

Our product range comprises machines and systems for processing steps.

The Technology Center wihich was built next to the Service Center was inaugurated in spring 2015. In this test and development center L.B. Bohle focusses on continuous processing together with partners from academia and industry.

The worldwide unique unit QbCon® 25 facilitates the continuous production of film-coated tablets via dierct compression, dry or wet granulation.

Continuous Manufacturing with dry granulation

 

Continuous Manufacturing with wet granulation

 

For more information about the L.B. Bohle technology and products for your continuous solid dosage production vistit our website:
www.continuous-production.com

 

QbCon® – Schedule Your Trials Now!

Fluid-bed processor / Fluid-bed granulator / Fluid-bed dryer

Using a tangential fluid bed system represents state of the art technology in pharmaceutical manufacturing for particle coating, granulation and drying.

With the innovative and patented Bohle Uni Cone BUC® process a complete fluidization is assured which leads to a high coating uniformities and high yields in the final product due to the absence if particle twinning. Bohle Uni Cone BUC ® is the productive, practical and precise alternative to conventional Wurster processing.

The BFS features a broad range of extension options for Bottom Tangential Spray Granulation as well as Bottom Tangential Spray Coating. All production systems are 12 bar shock pressure resistant.

Twin-screw granulator

Continuous processes are strongly increasing in the pharmaceutical industry. In 2011, L.B. Bohle introduced the first Bohle Conit Granulator BCG® - a twin screw granulator with a downstream dryer. A new version of the twin screw granulator BCG was unveiled in 2017!

High-shear granulator / High-shear processor

The Granumator® GMA is a granulation system specifically optimized for pharmaceutical applications. The impeller is designed for high shear and compression, ensuring effective granulation. The chopper prevents excessive granule growth and distributes the granulating liquid within the product.

The High Shear Granulator GMA is designed for through-the-wall installation. The container is connected to the system head via electrically driven lifting cylinders and can be lowered for inspection, for example. The granulation system GMA is 12 bar shock pressure resistant.

Single-Pot granulator / Single-pot processor

The VMA single pot granulator is a granulating and drying system specifically optimized for pharmaceutical applications. The Vagumator® single pot systems are designed for closed, dust-free processing of pharmaceutical granules from charging through dicharge including in-line milling.

Mixing, granulation and drying cycles are completed in a single machine under contained conditions.

The impeller, with its high shear and compression, ensures effective granulation. The chopper prevents excessive granule growth and distributes the granulating liquid within the product.

Granulation suite / Granulation module

The individual components of the High Shear Granulator GMA, wet sieve BTS, Fluid Bed System BFS and Bohle Uni Cone BUC®, cyclone separator and dry sieve BTS are optimally integrated into the Compact Unit. This integration covers process, cleaning, control and explosion protection as well as qualification.

The Compact Unit is a compelling solution when traditional wet granulation must be realized economically and ergonomically. Featuring many technological advances and inherent safety considerations, the Compact Unit creates an industry benchmark.

Small footprint, flexible application and smooth production processes are decisive criteria for investment in the pharmaceutical granulation system. In this respect, L.B. Bohle sets standards with the Compact Unit.

Conical Mill / Conical Sieve

Thanks to the fast rotor and patented impeller, the Bohle Turbo Sieve ensures efficient operation. Significant features include vertical arrangement with conical hole or friction sieve, angled drive in the rotor for direct power transmission and high throughputs.

Hammer Mill BTM

Even for most complicated products, the user-friendly, modular and compact cGMP design of the Turbo Mill BTM ensures excellent throughput capacities. Important features: easy transport on a mobile undercarriage as well as height adjustability.

Continuous ManufacturingTechnology Center

Continuous Manufacturing

From Powder to the coated tablet: The unique feature of the production unit QbCon® is that the tablet production can be implemented either without granulation or with dry or wet granulation, in one system.

Test QbCon® Now

Complete Solid Dosage ProductionService Center

The Bohle Service Center enables the presentation and testing from our machines as well as the executions of workshops and tutorials.

to Service Center