Constant and continuous drying must be guaranteed to seamlessly connect to continuous wet granulation. With the BCD continuous fluid bed dryer, L.B. Bohle now enables the continuous drying of granules for the first time. Until now, dryers only existed on the market that did not meet the requirements of continuous drying, they only form sub-batches. However, in the BCD, L.B. Bohle implement a truly continuous process without interruptions. The results from the laboratory scale are also easily scalable to production size.

Continuously produced wet granules fall gravimetrically into the dryer without any further necessary transport steps and are then dried in a continuous process. The constant conveying of the wet granules from the dryer inlet towards its outlet is achieved by a controllable movement. This ensures gentle and very uniform drying. The movement is so gentle that there is almost no resulting back-mixing and all granules (even in different particle sizes) are dried for the same length of time. Innovative product filters guarantee service lives of days without having to interrupt the continuous granulation process. As a result, there is no loss of quality, even with finely micronized drugs.

The BCD fluid bed dryer is the ideal tool for the continuous manufacturing of high-quality products on a laboratory and production scale. The implementation of Process Analytical Technology (PAT), for example for constant in-line determination of the granule moisture content and for feedback control of the process, also ensures process and product quality. The BCD can be used within the QbCon^® 1 laboratory machine for throughputs of 0.25-2.5 kg/h or for production sizes up to 25 kg/h. It is available in different sizes to make production more efficient and higher quality.

Advantages of the BCD continuous fluid bed dryer:

• Fully continuous drying without the formation of sub-batches for the first time
• Simple set-up and convenient operation
• Very long service life of the product filters without the need to interrupt the process
• PAT probes only in contact with dry product – no unwanted product adhesion
• Very short mean residence times and narrow residence time distributions
• Small in-process volume
• Selective rejection of "bad product" possible
• Four degrees of freedom to control the drying process
• Uniform drying across all particle sizes
• Gentle drying process: No formation of fines in the process, even for highly porous granules

Your contact for the Bohle Continuous Dryer:

Burkhard Schmidt - Sales Director

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+49 2524 - 93 23 0

 Topics of the current issue:

• L.B. Bohle in times of COVID-19
• Revenue up again in 2019
• Product innovations despite fair cancellations
• Machinery for new plant in Russia
• Service locations all over the world
• Trade fair success in India
• Lifting columns optimize the packaging system
• New company restaurant
• L.B. Bohle honours employees

Read the current issue

Innovativ chronicle

Dear valued customers and partners,

The current situation is very special and extremely challenging for all of us. The COVID-19 pandemic conducts our daily life and our business.

We have taken some actions to secure our business to stay in contact with our customers:

1. Implementation of strictly hygienic measures according to the German RKI.
2. Working in two shifts to reduce the number of employees in our facilities and shrinking the personal contacts. This includes the benefit that we enlarge our working hours and the accessibility for our customers.
3. Reduction of visits and meeting to the absolute necessary. Furthermore, we have postponed all events.
4. We have increased our hotline support to stay easily in touch with our customers globally. You can reach us via phone, e-mail or our contact form on our website www.lbbohle.com.

All our actions are taken under the preference to secure our business relations and to keep our operation safely running.

All the best for you, your families and enterprises! Stay healthy!

Contact:

www.lbbohle.com

+49 2524 - 93 23 0

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 Topics of the current issue:

• Lorenz Bohle Celebrates 80th Birthday
• Agent Meeting in Spring
• New Lifting Column with Small Footprint
• Conical Mill BTS with RFID Equipment
• Steve Chahidi Strengthens Sales Team
• Bohle and Korsch Together at Interphex
• APV Seminars at the Service Center
• Start of Construction Work for New Canteen
• Thomas Altefrohne Wins Young Welders Competition
• Christel Wienker with L.B. Bohle for 35 years

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Innovativ chronicle

Permanent Control in the Sieving Process

The size reduction of pharmaceutical solids is a crucial step in the process of tablet production and has a significant influence on the quality of the final product. The required particle size distribution correlates with desired release characteristics. Therefore, the choice of the correct machine setup for the crushing process is critical for product quality. This means that the correct sieve insert must be selected and installed for a sieving machine.
For years now, the Bohle Turbo Sieve BTS 200 has been meeting the highest standards of process reliability thanks to its modern control system with recipe and user management. The sieving process can only be started by authorized operators. However, the operator is still solely responsible for installing the appropriate sieve insert.

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Bohle developers optimise lifting column for automated processes

In the pharmaceutical solids industry, lifting devices in the form of lifting columns have been an indispensable aid in performing a great variety of tasks for many years. For example, lifting columns are used to feed tablet presses or coaters or in complex manufacturing lines.

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By Ajay Pazhayattil, Marzena Ingram, Ramana Kumar, Sudhakara Rao, and Robin Meier

Continuous manufacturing (CM) is an integrated process that consists of a series of two or more unit operations. In such a process, the input materials are continuously fed into and transformed within the process, and the processed output materials are continuously removed from the system.¹ Benefits for generic drug manufacturers of adopting a continuous manufacturing platform include the lower cost of goods sold (COGS), eliminating batch to batch variability, and gaining enough flexibility and agility in production to respond to market demands without compromising product quality.

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Granulation is an important process step in the manufacturing of pharmaceutical products. The goal of granulation is to take fine, non-compactable powders and turn them into coarser agglomerates that can then be pressed into tablets. Agglomerates can be composed of dry, solid granules, where each granule represents an agglomerate of primary particles with sufficient solidity. Granulates may be used directly as pharmaceuticals or serve as an intermediate product in the manufacturing of tablets or capsules. Tablets are the most commonly used form of drug delivery as they are not only easy to produce but can also be produced in large quantities.

Granulation is divided into two categories, dry and wet granulation. In the wet granulation process, dry primary powder particles are mixed with an aqueous or solvent-based granulation fluid and solidified. In the dry granulation process, agglomerates are created through mechanical pressure alone. 

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INTERPHEX 2019 will take place in New York from April 02 – 04, 2019. We welcome you to visit us at L.B. Bohle’s booth #2954. At this year’s INTERPHEX L.B. BOHLE is going to highlight several machines from our product portfolio.

You will find the following exhibits at our booth:

• Tablet Coater BTC 100
• Roller Compactor BRC 25
• Hammer Mill BTM 150
• Conical Sieve BTS 200

Enter the world of advanced process technology. In a combined booth, L.B. Bohle and Korsch AG will both present numerous equipment innovations in solid dosage manufacturing, material handling, for batch and continuous process technology. Come and experience our state-of-the-art equipment, meet our experts, and discuss individual machine capabilities or integrated process lines. We look forward to welcoming you!

SAVE THE REGISTRATION FEE AND REGISTER HERE

Record number of participants at the Agent Meeting

The worldwide L.B. Bohle sales team meets every three years in spring for a two-day workshop in Ennigerloh. The process engineers from the Service Center and Technology Center as well as the area sales managers informed the more than 60 participants about the latest innovations and technical advancements.
"We have introduced many new products and features, especially in the last three years. Starting with the QbCon® continuous technology, through to the BCG twin screw granulator to the new HS 1000 SL lifting column and the b.sure® monitoring app," managing director Tim Remmert lists the innovations. "For this reason, it is essential that our agents are brought up to date with the latest knowledge about our technologies," says Remmert, explaining the importance of the agent meeting.    

Tight programme in theory and practice

The two-day meeting focused on demonstrations and lectures on the extensive product range for batch and continuous processes. "We have high-tech products that need explaining. Our agents need to understand the technology so they can communicate its USP," continues Tim Remmert. "It is also extremely important for the agents to be able to talk to each other and share experiences."

Sales growth thanks to larger network

L.B. Bohle's global network of agents also grew as part of globalisation and the worldwide interdependence of business and production processes. Customers can now find professional contacts on all continents who provide information about the product portfolio and support them during the project phase.

"I can still remember the first few years when we welcomed ten agents here. Now it's over 60!", says Lorenz Bohle, Chairman of the Advisory Board, proudly looking at the company's development. "This is a clear sign that we have developed from a niche manufacturer of special machinery to a globally recognised brand as a supplier to the largest corporations in the pharmaceutical industry."