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The size reduction of pharmaceutical solids is a crucial step in the process of tablet production and has a significant influence on the quality of the final product. The required particle size distribution correlates with desired release characteristics. Therefore, the choice of the correct machine setup for the crushing process is critical for product quality. This means that the correct sieve insert must be selected and installed for a sieving machine.
For years now, the Bohle Turbo Sieve BTS 200 has been meeting the highest standards of process reliability thanks to its modern control system with recipe and user management. The sieving process can only be started by authorized operators. However, the operator is still solely responsible for installing the appropriate sieve insert.
In the pharmaceutical solids industry, lifting devices in the form of lifting columns have been an indispensable aid in performing a great variety of tasks for many years. For example, lifting columns are used to feed tablet presses or coaters or in complex manufacturing lines.
By Ajay Pazhayattil, Marzena Ingram, Ramana Kumar, Sudhakara Rao, and Robin Meier
Continuous manufacturing (CM) is an integrated process that consists of a series of two or more unit operations. In such a process, the input materials are continuously fed into and transformed within the process, and the processed output materials are continuously removed from the system.1 Benefits for generic drug manufacturers of adopting a continuous manufacturing platform include the lower cost of goods sold (COGS), eliminating batch to batch variability, and gaining enough flexibility and agility in production to respond to market demands without compromising product quality.
Granulation is an important process step in the manufacturing of pharmaceutical products. The goal of granulation is to take fine, non-compactable powders and turn them into coarser agglomerates that can then be pressed into tablets. Agglomerates can be composed of dry, solid granules, where each granule represents an agglomerate of primary particles with sufficient solidity. Granulates may be used directly as pharmaceuticals or serve as an intermediate product in the manufacturing of tablets or capsules. Tablets are the most commonly used form of drug delivery as they are not only easy to produce but can also be produced in large quantities.
Granulation is divided into two categories, dry and wet granulation. In the wet granulation process, dry primary powder particles are mixed with an aqueous or solvent-based granulation fluid and solidified. In the dry granulation process, agglomerates are created through mechanical pressure alone.
INTERPHEX 2019 will take place in New York from April 02 – 04, 2019. We welcome you to visit us at L.B. Bohle’s booth #2954. At this year’s INTERPHEX L.B. BOHLE is going to highlight several machines from our product portfolio.
You will find the following exhibits at our booth:
Enter the world of advanced process technology. In a combined booth, L.B. Bohle and Korsch AG will both present numerous equipment innovations in solid dosage manufacturing, material handling, for batch and continuous process technology.
Come and experience our state-of-the-art equipment, meet our experts, and discuss individual machine capabilities or integrated process lines. We look forward to welcoming you!
SAVE THE REGISTRATION FEE AND REGISTER HERE
The worldwide L.B. Bohle sales team meets every three years in spring for a two-day workshop in Ennigerloh. The process engineers from the Service Center and Technology Center as well as the area sales managers informed the more than 60 participants about the latest innovations and technical advancements.
"We have introduced many new products and features, especially in the last three years. Starting with the QbCon® continuous technology, through to the BCG twin screw granulator to the new HS 1000 SL lifting column and the b.sure® monitoring app," managing director Tim Remmert lists the innovations. "For this reason, it is essential that our agents are brought up to date with the latest knowledge about our technologies," says Remmert, explaining the importance of the agent meeting.
The two-day meeting focused on demonstrations and lectures on the extensive product range for batch and continuous processes. "We have high-tech products that need explaining. Our agents need to understand the technology so they can communicate its USP," continues Tim Remmert. "It is also extremely important for the agents to be able to talk to each other and share experiences."
L.B. Bohle's global network of agents also grew as part of globalisation and the worldwide interdependence of business and production processes. Customers can now find professional contacts on all continents who provide information about the product portfolio and support them during the project phase.
"I can still remember the first few years when we welcomed ten agents here. Now it's over 60!", says Lorenz Bohle, Chairman of the Advisory Board, proudly looking at the company's development. "This is a clear sign that we have developed from a niche manufacturer of special machinery to a globally recognised brand as a supplier to the largest corporations in the pharmaceutical industry."
The pharmaceutical production of tablets is practically unthinkable without the use of a sieve or a mill. These are needed whenever active and inactive materials are handled and tablets or other products are being manufactured.
Sieving machines and mills are used for milling solids to reduce their size. This fulfils two purposes: Firstly, it enlarges the particle surface which increases the speed of dissolution. Secondly, it evens out differences between particle sizes to ensure that mixing can be homogeneous.
Due to their versatility, milling and sieving machines play a crucial role in pharmaceutical production. They can be integrated into complex production lines, for example for filling/emptying or transfer operations at process machines, or for filling and decanting containers.
Decisive factors for the use and functionality of mills and sieves include their flexibility and the fact that the equipment requires very little room. In particular in pharmaceutical clean rooms where there is often not much space, the small footprint of these systems is a great benefit. In addition, certain sieving systems and mills are equipped with built-in lifting columns so that they can be integrated into almost any conceivable process scenario.
In the pharmaceutical industry, granulation plays a key role in the production of solid dosage forms – particularly due to the pressure of rising costs. Granulation aims to form coarser agglomerates from fine powder. Agglomerates may consist of fixed, dry grains, and each grain is an agglomeration of powder particles of sufficient strength. Granulates can be used directly as pharmaceuticals or can serve as an intermediate in the production of tablets or capsules.
L.B. Bohle Maschinen + Verfahren GmbH (Ennigerloh) offers a wide range of granulation solutions. The Bohle portfolio for manufacturing oral solids includes complete production systems as well as stand-alone machines. In addition, the mechanical engineering company specialist has developed and delivered a large number of containment applications for the pharmaceutical and food industries. An introduction to granulation concepts, fields of application and added value for customers is given below.
From Powder to the coated tablet: The unique feature of the production unit QbCon® is that the tablet production can be implemented either without granulation or with dry or wet granulation, in one system.
Test QbCon® Now
The Bohle Service Center enables the presentation and testing from our machines as well as the executions of workshops and tutorials.
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