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The 2nd Workshop on Continuous Pharmaceutical Manufacturing was a huge success. More than 40 particpants from all over the world informed tehmselves about current trends and strategies.
Further impressions of this event.
For two days in the mid of September, Ennigerloh was the place to be for experts and users in the pharmaceutical industry doing research in the area of continuous manufacturing: They accepted the invitation of L.B. Bohle Maschinen + Verfahren GmbH to the “2nd Continuous Pharmaceutical Manufacturing Symposium“ to discuss the processes of the future. “We are in constant exchange with scientists are at the technological forefront when it comes to continuous processes for the pharmaceutical industry," reports Tim Remmert, Managing Director.
“For pharmaceutical manufacturers, continuous manufacturing means shorter time to market, more flexible production even of small batches and highest precision and quality due to comprehensive process monitoring and control,” added Thorsten Wesselmann, Technical Director. This saves time and costs for our customers in the pharmaceutical industry. More than 40 guests from Asia, South America, North America and, last but not least, Europe exchanged views on the current state of developments and discussed future steps at the symposium. At the globally unique Technology Center the participants had the chance to get a first-hand impression of the sensor technology measurement, analysis and control technology in practical application.
Download the program and agenda of our exclusive 3-day practical hands-on workshop by leading experts with industrial, academial and regulatory experience.
In the pharmaceutical industry, one term is becoming increasingly important: containment. It describes the process of containing a substance within a defined space, a method that is suitable for protecting operators and the environment in case of high toxicity and product reactivity. At the same time, containment prevents dust, gases or vapours from being released into the environment and contaminating the product.
More than 60 percent of pharmaceutical products are produced as tablets, capsules, lozenges or similar solids. Especially in new products the active pharmaceutical ingredients (APIs) are becoming increasingly more potent. In some markets, the segment for high potency active pharmaceutical ingredients (HPAIs) is growing in the double-digit range, especially driven by oncology medication.
In addition to requirements set by manufacturing guidelines, it is essential that the product is safe for the machine operator and, of course, for the patient. As a result, machine manufacturers such as L.B. Bohle are faced with new challenges in all toxicity classes in which customers want to use plants and processes. In 2017, numerous customers with special specifications turned to the independent medium-sized family-owned company requesting, among other things, containment solutions for film coating applications and a dry granulation process.
L.B. Bohle introduces the process tracking app b.sure® at ACHEMA. b.sure® is a monitoring application that keeps track of your process at all times. In comparison to other solutions on the market that operate via cloud, b.sure® keeps the data in the company.
b.sure® is web-based and can be opened either on the respective device or via the sent email.
This year´s ACHEMA in Frankfurt (Germany) was a huge success for the German machine builder L.B. Bohle. At the expansive booth, they shared with tablet press specialists, Korsch AG, interested parties and customers were able to find out more about current sold dosage production trends under the motto "Your Process in Mind".
As the highlight of the trade fair, L.B. Bohle focused on QbCon® 1, the market's first continuous twin-screw granulator with an integrated, truly continuous dryer. The trade show visitors were enthusiastic about this unique new machine, because QbCon® 1 accomplishes truly continuous drying and granulation with very narrow and reproducible dwell times in the dryer, as well as stable quality of the granules in terms of moisture and particle size for the very first time.
By using PAT, the production process can be tracked inline. This leads to constant production of high-quality products, high patient safety, lower costs, a better process understanding and optimized process control. Complete control and monitoring of the entire process takes place via a touch panel. QbCon® 1 requires little space and is suitable for the lowest throughputs (nominal throughput: 0.5-2.5 kg / h), but throughput can be increased far greater depending on the product.
Just from seeing QbCon® 1 at the fair, customers have already arranged to get a closer look and test this machine at the Bohle facility.
This year´s ACHEMA in Frankfurt (Germany) was a huge success for the German machine builder L.B. Bohle. At the expansive booth, they shared with tablet press specialists, Korsch AG, interested parties and customers were able to find out more about current sold dosage production trends under the motto "Your Process in Mind".
Our workshop will be offering a practical and theoretical introduction to continuous processing of oral solid dosage formulations.
It will take place in our Technology Center at the state-of-the-art modular continuous production line QbCon® in Ennigerloh, Germany. Experience our unique unit as it facilitates continuous tablet production via direct compression, dry and wet granulation.
TOPICS:
Continuous direct compression
Continuous dry granulation
Continuous wet granulation
And as a highlight: The first truly continuous drying in the market
Who should Attend?
• Engineers, researchers, operators and decision makers with background in the pharmaceutical industry, academia or regulatory bodies.
• If you are operating in batch today – no problem. The workshop considers the future of OSD- processing within the pharmaceutical industry.
For L.B. Bohle, direct customer contact has been one of the decisive criteria for joint success since it was founded. The close tie with users ensures that developers from technology and research regularly learn about new requirements placed on machines and processes.
“The demand for technology for coating miniature tablets has recently been on the rise. As early as in 2009, we were able to develop a slotted coater drum as part of a customer project. At that time, a customer needed a coater to film miniature tablets and pellets with a diameter of less than three millimetres - a requirement that conventional systems with standard perforation had not been able to meet,” Tim Remmert outlines the task at that time.
Miniature tablets have already been established as a dosage form for several years and offer the advantage that several tablets can be administered together if necessary to achieve the required individual dose. They are especially suited for multi-particle dosage forms as they can be individually and flexibly dosed. As a result, they can either be filled into capsules or sachets or applied with miniature tablet dispensers. Often the small cores are coated to provide sufficient stability.Besides functionality, swallowing as well as taste and odor are improved by the film coverings.
From Powder to the coated tablet: The unique feature of the production unit QbCon® is that the tablet production can be implemented either without granulation or with dry or wet granulation, in one system.
Test QbCon® Now
The Bohle Service Center enables the presentation and testing from our machines as well as the executions of workshops and tutorials.
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