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In the pharmaceutical industry, one term is becoming increasingly important: containment. It describes the process of containing a substance within a defined space, a method that is suitable for protecting operators and the environment in case of high toxicity and product reactivity. At the same time, containment prevents dust, gases or vapours from being released into the environment and contaminating the product.
More than 60 percent of pharmaceutical products are produced as tablets, capsules, lozenges or similar solids. Especially in new products the active pharmaceutical ingredients (APIs) are becoming increasingly more potent. In some markets, the segment for high potency active pharmaceutical ingredients (HPAIs) is growing in the double-digit range, especially driven by oncology medication.

In addition to requirements set by manufacturing guidelines, it is essential that the product is safe for the machine operator and, of course, for the patient. As a result, machine manufacturers such as L.B. Bohle are faced with new challenges in all toxicity classes in which customers want to use plants and processes. In 2017, numerous customers with special specifications turned to the independent medium-sized family-owned company requesting, among other things, containment solutions for film coating applications and a dry granulation process.

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L.B. Bohle introduces the process tracking app b.sure^® at ACHEMA. b.sure^® is a monitoring application that keeps track of your process at all times. In comparison to other solutions on the market that operate via cloud, b.sure^® keeps the data in the company.

b.sure^® is web-based and can be opened either on the respective device or via the sent email.

Further information

This year´s ACHEMA in Frankfurt (Germany) was a huge success for the German machine builder L.B. Bohle. At the expansive booth, they shared with tablet press specialists, Korsch AG, interested parties and customers were able to find out more about current sold dosage production trends under the motto "Your Process in Mind".

QbCon^® 1 - The Exhibition Highlight

As the highlight of the trade fair, L.B. Bohle focused on QbCon® 1, the market's first continuous twin-screw granulator with an integrated, truly continuous dryer. The trade show visitors were enthusiastic about this unique new machine, because QbCon® 1 accomplishes truly continuous drying and granulation with very narrow and reproducible dwell times in the dryer, as well as stable quality of the granules in terms of moisture and particle size for the very first time.
By using PAT, the production process can be tracked inline. This leads to constant production of high-quality products, high patient safety, lower costs, a better process understanding and optimized process control. Complete control and monitoring of the entire process takes place via a touch panel. QbCon® 1 requires little space and is suitable for the lowest throughputs (nominal throughput: 0.5-2.5 kg / h), but throughput can be increased far greater depending on the product.
Just from seeing QbCon® 1 at the fair, customers have already arranged to get a closer look and test this machine at the Bohle facility.

This year´s ACHEMA in Frankfurt (Germany) was a huge success for the German machine builder L.B. Bohle. At the expansive booth, they shared with tablet press specialists, Korsch AG, interested parties and customers were able to find out more about current sold dosage production trends under the motto "Your Process in Mind".

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For L.B. Bohle, direct customer contact has been one of the decisive criteria for joint success since it was founded. The close tie with users ensures that developers from technology and research regularly learn about new requirements placed on machines and processes.
“The demand for technology for coating miniature tablets has recently been on the rise. As early as in 2009, we were able to develop a slotted coater drum as part of a customer project. At that time, a customer needed a coater to film miniature tablets and pellets with a diameter of less than three millimetres - a requirement that conventional systems with standard perforation had not been able to meet,” Tim Remmert outlines the task at that time.

Cores with a diameter of only 1.5 millimetres

Miniature tablets have already been established as a dosage form for several years and offer the advantage that several tablets can be administered together if necessary to achieve the required individual dose. They are especially suited for multi-particle dosage forms as they can be individually and flexibly dosed. As a result, they can either be filled into capsules or sachets or applied with miniature tablet dispensers. Often the small cores are coated to provide sufficient stability.Besides functionality, swallowing as well as taste and odor are improved by the film coverings.

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L.B. Bohle Maschinen + Verfahren GmbH is going to unveil the first truly CONTINUOUS twinscrew Granulator and Dryer on the market at Interphex 2018 in New York. QbCon^® 1 guarantees unique technology for your R&D.

Learn more about QbCon^® 

Topics of the current issue:

•     Total Revenue Increases to More Than € 50 Million in 2017
•     Containment in Process Technology
•     Workshop on Continuous Manufacturing - Ennigerloh Ahead of the Global Game
•     New General Sales Manager - Burkhrad Schmidt assumes top position
•     Closer to the Customer - Service subsidiary for Switzerland
•     Slotted Coating Drum - Solution for tablet coating
•     Plant 2 - 600 m2 more space for construction
•     Trade Fair Highlights 2018
•     Long-standing employees - Loyalty pays off

Read the current issue

Innovativ chronicle

The L.B. Bohle Maschinen + Verfahren GmbH offers quality at the highest level. The result of the certification carried out at the beginning of the year underlines this quality standard.
As part of the certification, the transition from ISO 9001: 2008 to the new ISO 9001: 2015 has been audited, proving that the requirements of the standard for QM systems DIN EN ISO 9001: 2015 are met.

The scope of the certification applies to all German locations and applies to the following areas:
Development, production, sales and service of machinery and equipment for the food and pharmaceutical industries.

L.B. Bohle is fulfilling all customer requirements and other requirements for product or service quality with distinction.

Download the Certificate