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Terms

CIP

Cleaning in Place; technical process in which surfaces with direct contact can be cleaned reproducibly and controllably through a specific cleaning process so that a previously defined cleaning condition is achieved . Cleaning system in the production machine .


Clean room

Separated production or laboratory area in the pharmaceutical industry.


Coater

Machine for coating tablets.


Coating (Coat)

With coating, a solution or dispersion is generally sprayed onto the tablets whereby the suspension agent evaporates at the same time. The aim is to mask the flavour, to achieve enteric coating or sustained release or to give the tablets a specific colour. Coating can be carried out using a coater (Bohle Tablet Coater BTC; Bohle Film Coater BFC) or fluid bed systems (Bohle Fluid Bed System BFS).


Compact unit

The individual components of the High Shear Granulator GMA, Wet sieve BTS 300 or 400, Bohle Fluid Bed System BFS and Bohle Uni Cone BUC® , cyclone separator and dry sieve BTS 200 are optimally integrated into the Compact Unit. This integration covers process, cleaning, control, explosion protection and zone concept as well as qualification


Compacting

A form of dry granulation, in which powder is retracted and compacted using counter - rotating rollers. The resulting flakes are shaped into the final granu l e form in the subsequent chopping step.


Containment

A containment system prevents the release of dust, gases or vapour emissions into the environment. For instance, a containment valve enables safe handling of highly sensitive and highly active pharmaceuticals during product transfer.


Continuous processes

Continuous processes are on the advance in the pharmaceutical industry. The major process characteristic is that the reactant is continuously infed and outfed to a machine. Th e aim is to achieve a perfect plug flow. Bohle offers continuous processes in granulation as well as in the coating segment. Coating is carried out in the semi-continuous coater KOCO® , granulation through the extruder and dry granulator BRC 25 and BRC 100, the extruder BCG and the Bohle Continuous Dryer BCD. Batch production is the alternative to continuous processes.


Extruder

Machine for processing thermoplastics via extrusion whereby a mass is pressed through a nozzle with a spe cific pressure.


FDA

Food and Drug Administration: US supervisory and monitoring authority of the pharmaceutical and food market.


Display # 

Technology CenterContinuous Manufacturing

From Powder to the coated tablet: The unique feature of the production unit QbCon® is that the tablet production can be implemented either without granulation or with dry or wet granulation, in one system.

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Service CenterComplete Solid Dosage Production

The Bohle Service Center enables the presentation and testing from our machines as well as the executions of workshops and tutorials.

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InnovativIssue: 2-2018

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