The twin-screw granulator BCG can be operated as stand-alone machine or fully integrated in the continuous manufacturing line by L.B. Bohle. Powder is added via gravimetric feeding and wetted by granulation liquid, which is fed by a high precision pump. Resulting granules are intermixed densified and leave the BCG through an automated connection to the fluid bed-dryer.

The flexible screws configuration facilitates the manufacturing of granules with different porosities that fulfil the requirements of the subsequent downstream drying and tableting processes.

Intelligent control concepts

Through intelligent control concepts in conjunction with PAT, such as NIR for in-line determination or continuous particle size analysis, granules are produced in highest quality. In this context, the machine’s communication with PAT allows to control the product quality, which is met by the automatic control of critical process parameters. Using a predefined Design-Space, consistently high product quality is ensured.

In comparison to batch granulation processes, the gain of efficiency, the reduction of waste material, smaller GMP footprint and lower operating costs are advantages of the continuous production.

Beneftis of the Twinscrew Granulator:

  • short process residence times < 1 min - 10 s
  •  fast and efficient reaction to process and quality deviations
  • reduction of machine footprint and GMP-area: the amount of produced granules is determined by the production time
  • thereby, elimination of scale-up issues
  • mixing and granulation in one step
  • possibility to implement 100 % in-line product quality-control
  • no disposal of failure batches – only non-conforming material is rejected
  • execution of experimental plans in shortest time

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Technology CenterContinuous processing starts here

The unique feature of this plant is that the tablet production can be implemented either without granulation or with dry or wet granulation, in one system.

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Service CenterReliable trials

The Bohle Service Center enables the presentation and testing from our machines as well as the executions of workshops and tutorials.

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InnovativIssue: 2-2017

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